AMPCs_EN_202201_V3

§ Self Renewal AMPCs Characters • Self renewal cells, Sca-1 and CD117, significant increased after introducing AMPCs. • Sca-1, full name stem Cells ANTI-1, is a cell membrane protein (GPI-AP) belonging to LY6 gene family, which can affect the generation of hematopoietic stem cells and repair and regenerate the heart. • CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells and belongs to receptor Tyrosine kinase TYPE III. When this receptor binds to stem cell factors, the formation of protein dimer will activate its intrinsic tyrosine kinase activity. It phosphorylates and activates signal transduction molecules in cells, further regulating cell survival, proliferation and differentiation.